Five years treatment with strontium ranelate reduces vertebral and nonvertebral fractures and increases the number and quality of remaining life-years in women over 80 years of age
Identifieur interne : 007855 ( Main/Exploration ); précédent : 007854; suivant : 007856Five years treatment with strontium ranelate reduces vertebral and nonvertebral fractures and increases the number and quality of remaining life-years in women over 80 years of age
Auteurs : Ego Seeman [Australie] ; Steven Boonen [Belgique] ; Frederik Borgström [Suède] ; Bruno Vellas [France] ; Jean-Pierre Aquino [France] ; Jutta Semler [Allemagne] ; Claude-Laurent Benhamou [France] ; Jean-Marc Kaufman [Belgique] ; Jean-Yves Reginster [Belgique]Source :
- Bone : (New York, NY) [ 8756-3282 ] ; 2010.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Femme, Personne âgée.
English descriptors
- KwdEn :
Abstract
Introduction: Longevity has resulted in a greater proportion of the population entering a time of life when increasing bone fragility and falls predispose to fractures, particularly nonvertebral fractures. Women over 80 years of age constitute 10% of the population but contribute 30% of all fractures and 60% of all nonvertebral fractures. Despite this, few studies have examined antifracture efficacy of treatments in this high-risk group and none has provided evidence for benefits beyond 3 years. Materials and methods: To determine whether strontium ranelate reduces the risk of vertebral and nonvertebral fractures during 5 years, we analyzed a subgroup of 1489 female patients over 80 years of age (mean 83.5 ± 3.0 years) with osteoporosis from the SOTI (spinal osteoporosis therapeutic intervention) and TROPOS (treatment of peripheral osteoporosis) studies randomized to strontium ranelate 2 g/d or placebo. All received a supplement of calcium plus vitamin D. Results: By intention to treat, vertebral fracture risk was reduced by 31% (relative risk, RR = 0.69; 95% confidence interval, CI 0.52-0.92), nonvertebral fracture risk by 27% (RR = 0.73; 95% CI 0.57-0.95), major nonvertebral fracture risk by 33% (RR = 0.67; 95% Cl 0.50-0.89) and hip fracture risk by 24% (RR = 0.76; 95% CI 0.50-1.15, not significant). Treatment was cost-saving as it decreased cost and increased QALYs and life-years. Discussion: Strontium ranelate safely produced a significant reduction in vertebral and nonvertebral fracture risk during 5 years in postmenopausal women over 80 years of age and was cost saving.
Affiliations:
- Allemagne, Australie, Belgique, France, Suède
- Berlin, Centre-Val de Loire, Midi-Pyrénées, Occitanie (région administrative), Province de Liège, Région Centre, Région wallonne, Svealand, Victoria (État), Île-de-France
- Berlin, Liège, Melbourne, Orléans, Stockholm, Toulouse, Versailles
- Université de Liège, Université de Melbourne
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Gent Department of Internal Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Reginster, Jean Yves" sort="Reginster, Jean Yves" uniqKey="Reginster J" first="Jean-Yves" last="Reginster">Jean-Yves Reginster</name><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>University of Liège</s1><s2>Liège</s2><s3>BEL</s3><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName><orgName type="university">Université de Liège</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">10-0210624</idno><date when="2010">2010</date><idno type="stanalyst">PASCAL 10-0210624 INIST</idno><idno type="RBID">Pascal:10-0210624</idno><idno type="wicri:Area/PascalFrancis/Corpus">002728</idno><idno type="wicri:Area/PascalFrancis/Curation">003858</idno><idno 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type="city">Melbourne</settlement><region type="état">Victoria (État)</region><settlement type="city">Melbourne</settlement></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Boonen, Steven" sort="Boonen, Steven" uniqKey="Boonen S" first="Steven" last="Boonen">Steven Boonen</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Leuven University Center for Metabolic Bone Diseases and Division of Geriatric Medicine</s1><s2>Leuven</s2><s3>BEL</s3><sZ>2 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Leuven University Center for Metabolic Bone Diseases and Division of Geriatric Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Borgstrom, Frederik" sort="Borgstrom, Frederik" uniqKey="Borgstrom F" first="Frederik" last="Borgström">Frederik Borgström</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>i3 Innovus</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>3 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>CHU Purpan</s1><s2>Toulouse</s2><s3>FRA</s3><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Aquino, Jean Pierre" sort="Aquino, Jean Pierre" uniqKey="Aquino J" first="Jean-Pierre" last="Aquino">Jean-Pierre Aquino</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Clinique Médicale de la Porte Verte</s1><s2>Versailles</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Versailles</settlement></placeName></affiliation></author><author><name sortKey="Semler, Jutta" sort="Semler, Jutta" uniqKey="Semler J" first="Jutta" last="Semler">Jutta Semler</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Immanuel Krankenhaus Rheumaklinik</s1><s2>Berlin</s2><s3>DEU</s3><sZ>6 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Benhamou, Claude Laurent" sort="Benhamou, Claude Laurent" uniqKey="Benhamou C" first="Claude-Laurent" last="Benhamou">Claude-Laurent Benhamou</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Hôpital de la Madeleine</s1><s2>Orléans</s2><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Centre-Val de Loire</region><region type="old region">Région Centre</region><settlement type="city">Orléans</settlement></placeName></affiliation></author><author><name sortKey="Kaufman, Jean Marc" sort="Kaufman, Jean Marc" uniqKey="Kaufman J" first="Jean-Marc" last="Kaufman">Jean-Marc Kaufman</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>U.Z. Gent Department of Internal Medicine</s1><s2>Gent</s2><s3>BEL</s3><sZ>8 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>U.Z. Gent Department of Internal Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Reginster, Jean Yves" sort="Reginster, Jean Yves" uniqKey="Reginster J" first="Jean-Yves" last="Reginster">Jean-Yves Reginster</name><affiliation wicri:level="4"><inist:fA14 i1="09"><s1>University of Liège</s1><s2>Liège</s2><s3>BEL</s3><sZ>9 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName><orgName type="university">Université de Liège</orgName></affiliation></author></analytic><series><title level="j" type="main">Bone : (New York, NY)</title><title level="j" type="abbreviated">Bone : (NY NY)</title><idno type="ISSN">8756-3282</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Bone : (New York, NY)</title><title level="j" type="abbreviated">Bone : (NY NY)</title><idno type="ISSN">8756-3282</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age</term><term>Clinical trial</term><term>Elderly</term><term>Fracture</term><term>Morphology</term><term>Osteoporosis</term><term>Quality of life</term><term>Strontium ranelate</term><term>Treatment</term><term>Vertebra</term><term>Woman</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Ranélate de strontium</term><term>Traitement</term><term>Vertèbre</term><term>Fracture</term><term>Qualité de vie</term><term>Femme</term><term>Age</term><term>Essai clinique</term><term>Personne âgée</term><term>Ostéoporose</term><term>Morphologie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Femme</term><term>Personne âgée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Introduction: Longevity has resulted in a greater proportion of the population entering a time of life when increasing bone fragility and falls predispose to fractures, particularly nonvertebral fractures. Women over 80 years of age constitute 10% of the population but contribute 30% of all fractures and 60% of all nonvertebral fractures. Despite this, few studies have examined antifracture efficacy of treatments in this high-risk group and none has provided evidence for benefits beyond 3 years. Materials and methods: To determine whether strontium ranelate reduces the risk of vertebral and nonvertebral fractures during 5 years, we analyzed a subgroup of 1489 female patients over 80 years of age (mean 83.5 ± 3.0 years) with osteoporosis from the SOTI (spinal osteoporosis therapeutic intervention) and TROPOS (treatment of peripheral osteoporosis) studies randomized to strontium ranelate 2 g/d or placebo. All received a supplement of calcium plus vitamin D. Results: By intention to treat, vertebral fracture risk was reduced by 31% (relative risk, RR = 0.69; 95% confidence interval, CI 0.52-0.92), nonvertebral fracture risk by 27% (RR = 0.73; 95% CI 0.57-0.95), major nonvertebral fracture risk by 33% (RR = 0.67; 95% Cl 0.50-0.89) and hip fracture risk by 24% (RR = 0.76; 95% CI 0.50-1.15, not significant). Treatment was cost-saving as it decreased cost and increased QALYs and life-years. Discussion: Strontium ranelate safely produced a significant reduction in vertebral and nonvertebral fracture risk during 5 years in postmenopausal women over 80 years of age and was cost saving.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>France</li><li>Suède</li></country><region><li>Berlin</li><li>Centre-Val de Loire</li><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li><li>Province de Liège</li><li>Région Centre</li><li>Région wallonne</li><li>Svealand</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Berlin</li><li>Liège</li><li>Melbourne</li><li>Orléans</li><li>Stockholm</li><li>Toulouse</li><li>Versailles</li></settlement><orgName><li>Université de Liège</li><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Seeman, Ego" sort="Seeman, Ego" uniqKey="Seeman E" first="Ego" last="Seeman">Ego Seeman</name></region></country><country name="Belgique"><noRegion><name sortKey="Boonen, Steven" sort="Boonen, Steven" uniqKey="Boonen S" first="Steven" last="Boonen">Steven Boonen</name></noRegion><name sortKey="Kaufman, Jean Marc" sort="Kaufman, Jean Marc" uniqKey="Kaufman J" first="Jean-Marc" last="Kaufman">Jean-Marc Kaufman</name><name sortKey="Reginster, Jean Yves" sort="Reginster, Jean Yves" uniqKey="Reginster J" first="Jean-Yves" last="Reginster">Jean-Yves Reginster</name></country><country name="Suède"><region name="Svealand"><name sortKey="Borgstrom, Frederik" sort="Borgstrom, Frederik" uniqKey="Borgstrom F" first="Frederik" last="Borgström">Frederik Borgström</name></region></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name></region><name sortKey="Aquino, Jean Pierre" sort="Aquino, Jean Pierre" uniqKey="Aquino J" first="Jean-Pierre" last="Aquino">Jean-Pierre Aquino</name><name sortKey="Benhamou, Claude Laurent" sort="Benhamou, Claude Laurent" uniqKey="Benhamou C" first="Claude-Laurent" last="Benhamou">Claude-Laurent Benhamou</name></country><country name="Allemagne"><region name="Berlin"><name sortKey="Semler, Jutta" sort="Semler, Jutta" uniqKey="Semler J" first="Jutta" last="Semler">Jutta Semler</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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